1) A 2-month, double-blind, placebo-controlled trial of 120 individuals with recurrent hemorrhoid flare-ups found that treatment with combined diosmin and hesperidin significantly reduced the frequency and severity of hemorrhoidal exacerbations.
Godeberge P. Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology. 1994;45:574-578.

2) Benefits of diosmin/hesperidin were seen in a double-blind trial of 100 individuals with bleeding hemorrhoids.
Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surg. 2000;87:868-872.

3) Double-blind, placebo-controlled trial of 100 individuals found that the bioflavonoid preparation relieved symptoms of hemorrhoid pain.
Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of flavanoids in the treatment of acute hemorrhoids. Angiology. 1994;45:566-573.

4) Bioflavonoid treatment was found to be better than rubber band ligation.
Ho YH, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial. Dis Colon Rectum. 2000;43:66-69.

5) Study found that diosmin/hesperidin reduces pain after hemorrhoid surgery.
La Torre F, Nicolai AP. Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial. Dis Colon Rectum . 2004 Mar 25.

6) Study showed that flavonoids reduce pain after hemorrhoidectomy.
Colak T, Akca T, Dirlik M, et al. Micronized flavonoids in pain control after hemorrhoidectomy: a prospective randomized controlled study. Surg Today . 2003;33:828-832.

7) 50 Patients in the study group were treated with a preparation of Plantain, study showed that it reduced bleeding.
Perez-Miranda M. Effect of fiber supplements on internal bleeding hemorrhoids. Hepatogastroenterology. Nov1996;43(12):1504-7.

8) Medical properties of Bilberry
Murray, Encyclopedia of Natural Medicine, second edition 1999. Murray MB. American Journal of Natural Medicine. 1997. Gruenwald PDR for Herbal Medicines - 1998.

9) Nattokinase Research
Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002.

10) Nattokinase Study
Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84(3):139-43.

11) Nattokinase Research
Sumi H, Hamada H, Mihara H. A novel strong fibrinolytic enzyme (nattokinase) in the vegetable cheese "natto." International